Sesamin

CAS Number: 607-80-7   |   Synonyms: (E)-5-(p-Hydroxystyryl)resorcinol; 3,4',5-Stilbenetriol; 3,5,4'-Trihydroxystilbene


Product InfoStructurePhysical PropertiesProduct DataTransportation DataSpecification Sheet

PRODUCT INFORMATION

Product Name:
Sesamin

Product Description:
Turning sesame into a skin specialty Sesamin is a naturally occurring lignan found in Sesamum Indicum. Sesamin has been scientifically referenced as an ingredient with UV-defense capabilities and may increase collagen synthesis in skin.

Quality Grade:
non-GMP

Usage Unit:
KG

Source:
-

Synonyms:
(E)-5-(p-Hydroxystyryl)resorcinol; 3,4',5-Stilbenetriol; 3,5,4'-Trihydroxystilbene

STRUCTURE

SKU: 607807 Category:
PHYSICAL PROPERTIES
S.NOPropertyValueReference
1Mp260-263 °C-
REFERENCES
S.NOTitleSourceNotesAuthor(s)DOI
15α-Reductase Inhibition and Melanogenesis Activity of Sesamin from Sesame Seeds for Hair CosmeticsChiang Mai J. Sci- Sesamin showed weak scavenging activity against DPPH with high lipid peroxidation inhibition and metal chelating activities - Hair Care potentials: Metal chelating may control balance of hair growth and hair loss in androgenic alopecia patients - Stimulates melanin synthesis in B18 melanoma cellsJiradej Manosroi, Pensak Jantrawut, Worapaka Manosroi, Prachya Kongtawelert and Aranya Manosroi-
2Inhibition of two stages of melanin synthesis by sesamol, sesamin and sesamolinAsian Pacific Journal of Tropical Biomedicine- Sesamin was shown to absorb UVB with higher absorbance than kojic acid and beta-arbutin - Sesamin showed high inhibition on cellular tyrosinase activitiesMontra Srisayam, Natthida Weerapreeyakul, Kwanjai Kanokmedhakul10.1016/j.apjtb.2017.09.013
3Protective Effects of Sesamin against UVB-Induced Skin Inflammation and Photodamage In Vitro and In VivoBiomolecules- ROS formation was significantly inhibited when treated with with sesamin over 10 uM - Sesamin pre-treatment showed decreased MMP-1, -3, and -9 expressions in Hs68 cells. Also showed upregulation of TIMP-1, which naturally inhibits MMPs. UVB protection benefits - Sesamin promoted collagen synthesis by regulating Smad expressions (5 uM sesamin decreased Smad3 and Smad7 expression, Smad suppresses collagen synthesis) - Anti-inflammatory use: i-NOS and COX-2 protein expression reduced after 5 uM sesamin treatment - Sesamin results in reduced UVB-induced inflammation in cells (translocation of NF-kB diminished)Tzu-Yu Lin, Po-Yuan Wu, Chien-Wei Hou, Ting-Yi Chien, Qiao-Xin Chang, Kuo-Ching Wen , Chien-Yih Lin and Hsiu-Mei Chiang10.3390/biom9090479
PRODUCT DATA

Molecular Formula:
C14H12O3

Molecular Weight:
354.4

EC Number:
-

Category:

Functional Categories:

Purity Value:
-

Storage Temperature:
-

INCI Name:
Sesamum Indicum Extract (Proposed)

TRANSPORTATION DATA

UN Class:
-

UN Packing Group:
-

Harmonized Tariff Number:
2911.00.50 00

UN Number:
-

Use Level:
-

China Registered:
Yes

SPECIFICATION SHEET

Rev No:
1

SPECIFICATION DATA

S.NOGroupingAnalytical TestSpecification
1-IdentityIR, TLC
2-AppearanceOff-white to pale-yellow microcryst. solid
3-Mp260-263 °C
4-Purity (HPLC)> 98%
5-LOD< 0.5%
6-Ash (residue on ignition)< 1%
7Heavy metals-< 10 ppm
8--Pb< 5 ppm
9--As< 2 ppm
10--Cd< 2 ppm
11--Hg< 1 ppm
12Total Aerobic (CFU/g)-<1,000 organisms/g
13-E. ColiNegative
14-SalmonellaNegative
15-Mold and Yeast<100 cfu/g
16Manufacturing and Regulatory Data--
17-Date of Manufacture-
18-Retest Date2 Years

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